Once an organic compound has been discovered and shown by one scientific group to have some type of desirable pharmacological activity, it will remain a mere curiosity unless a completely different group of scientists incorporate the compound in a formulation that facilitates its activity. The various topics outlined in this brief introduction and overview of the preformulation development of solid dosage forms. A more rational view is that the preformulation stage of drug development is really only half-complete at this stage, and that the program of drug development is not complete until it is fully understood how that API interacts with the excipients that will make up the remainder of its formulation. However, all of this requires a broad basis of understanding regarding the API and its possible interactions with excipients materials and a thorough understanding of the range of excipients required to achieve the pharmacological profile that is sought for the API.
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